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Inventi Impact: Animal Models & Cell Assays

Articles

  • Inventi:pac/29296/19
    Biomarker Analysis of Orally Dosed, Dual Active,\nMatrix Metalloproteinase (MMP)-2 and MMP-9\nInhibitor, AQU-118, in the Spinal Nerve Ligation\n(SNL) Rat Model of Neuropathic Pain
    Research 2019 : July - September
    Mei Yee Kwan, Anthony Choo, Taleen Hanania, Afshin Ghavami, Jose Beltran, John Shea, Amidi Barboza, Andrew Hu, Marcie Fowler, Venugopal Rao Neelagiri, Irving Sucholeiki

    There is an unmet medical need for the development of non-addicting pain therapeutics\nwith enhanced efficacy and tolerability. The current study examined the effects of AQU-118, an orally\nactive inhibitor of metalloproteinase-2 (MMP-2) and MMP-9, in the spinal nerve ligation (SNL)\nrat model of neuropathic pain. Mechanical allodynia and the levels of various biomarkers were\nexamined within the dorsal root ganglion (DRG) before and after oral dosing with AQU-118. The rats\nthat received the SNL surgery exhibited significant mechanical allodynia as compared to sham\ncontrols. Animals received either vehicle, positive control (gabapentin), or AQU-118. After SNL\nsurgery, the dorsal root ganglion (DRG) of those rats dosed with vehicle had elevated messenger\nRNA (mRNA) expression levels for..............

    How to Cite this Article
    Attribution/ CC Compliant Citation: Kwan, Mei Yee, et al; Biomarker Analysis of Orally Dosed, Dual Active, Matrix Metalloproteinase\n(MMP)-2 and MMP-9 Inhibitor, AQU-118, in the Spinal Nerve Ligation (SNL) Rat Model of Neuropathic Pain; International journal of\nmolecular sciences 20.4 (2019): 811.\nhttps://doi:10.3390/ijms20040811\nhttp://creativecommons.org/licenses/by/4.0/\n\nSome formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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